apgwamide peptide for sale

Premium APGWamide Peptide for Sale – Direct from Shanghai Manufacturer

Neuropeptides are fundamental to understanding nervous system function, development, and behavior across the animal kingdom. APGWamide, a highly conserved tetrapeptide first identified in mollusks, has become an invaluable research tool for scientists investigating inhibitory neurotransmission, reproductive biology, and neuronal signaling pathways . If you are searching for “APGWamide peptide for sale” for your laboratory investigations, you need a manufacturing partner who understands the specificity of this neuropeptide and can deliver the purity your research demands. That partner is Apeptide (Shanghai) Co., Ltd.

We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, catalog peptides, fluorescent dyes, and amino acids. When you purchase APGWamide peptide for sale from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller.

Understanding APGWamide: The Conserved Molluscan Neuropeptide

APGWamide (Ala-Pro-Gly-Trp-NH₂) is a tetrapeptide that was first purified from the ganglia of the African giant snail (Achatina fulica Ferussac) . Despite its small size of only four amino acids, this peptide plays significant roles in nervous system function and reproductive development across multiple molluscan species .

Key Characteristics

• Sequence: H-Ala-Pro-Gly-Trp-NH₂ (APGW-NH₂)

• Molecular Formula: C₂₁H₂₈N₆O₄

• Molecular Weight: 428.48 g/mol

• CAS Number: 126675-52-3

• PubChem CID: 50064302

• Source: Synthetic

• Form: Lyophilized powder

• Purity: ≥99% (verified by HPLC)

• Appearance: White to off-white powder

Mechanism of Action

APGWamide functions as an inhibitory neurotransmitter in molluscan neurons. Research demonstrates that this peptide inhibits (hyperpolarizes) more than half of the Achatina neuron types tested . Under voltage clamp conditions, it produces an outward current with increased membrane conductance, specifically through enhanced membrane permeability to potassium ions (K⁺) . The half-maximal effective concentration (ED₅₀) is approximately 6.2 × 10⁻⁶ M (95% confidence limit: 5.0-7.8 × 10⁻⁶ M), with a maximal response (Emax) of 3.9 ± 0.2 nA .

Why APGWamide Matters in Research

APGWamide is highly conserved among mollusks and has been identified in multiple species including the African giant snail (Achatina fulica), freshwater great pond snail (Lymnaea stagnalis), octopus (Octopus vulgaris), and spindle shell (Fusinus ferrugineus) . Recent research has also characterized APGWamide signaling systems in the marine mollusk Aplysia californica, identifying three distinct receptors with EC₅₀ values of 45 nM, 2100 nM, and 2600 nM, respectively .

Key Research Applications

Scientists seek APGWamide peptide for sale for various laboratory investigations:

Species Distribution

APGWamide has been characterized across diverse molluscan species:

• Gastropods: Achatina fulica , Lymnaea stagnalis , Aplysia californica , Berghia stephanieae

• Bivalves: Mytilus edulis

• Cephalopods: Sepia officinalis (cuttlefish) , Octopus vulgaris

The Critical Importance of Quality for APGWamide Research

When you purchase APGWamide peptide for sale, quality parameters are non-negotiable. APGWamide requires precise synthesis to ensure correct C-terminal amidation—the Wamide motif (Trp-NH₂) is essential for receptor activation . Low-quality materials may lack proper amidation or contain truncated sequences that completely invalidate research results.

The Apeptide Quality Standard

• 99% Purity Guarantee: Verified by High-Performance Liquid Chromatography (HPLC)

• Mass Spectrometry: Molecular weight confirmation (428.48 g/mol expected)

• Amino Acid Analysis: Sequence verification (Ala-Pro-Gly-Trp-NH₂)

• Peptide Content Determination: Accurate net peptide weight (>80% typical)

• C-Terminal Amidation Confirmation: Essential for biological activity

• Counterion Analysis: TFA salt content specified (affects solubility)

• Batch-Specific COAs: Full traceability with Certificates of Analysis

• Stability Testing: Ensuring integrity from our lab to yours

• Endotoxin Testing: <0.05 EU/mg available for cell culture applications

Why Purity Matters Specifically for APGWamide Research

• Receptor Binding Studies: EC₅₀ values range from 45-2600 nM; impurities skew affinity measurements

• Electrophysiology: Outward current measurements (3.9 ± 0.2 nA) require pure compounds

• In Vivo Studies: Threshold doses as low as 10⁻¹⁶ moles demand consistent materials

• Imposex Research: Reproductive toxicity studies require documented purity

 Why Source APGWamide from Apeptide

When you search for “APGWamide peptide for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice.

Complete Transparency

• Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.

• Manufacturing Expertise: Decades of combined experience in peptide synthesis and biochemical production.

• No Middlemen: You pay manufacturer-direct pricing, not reseller markups.

Technical Expertise

Our team understands the specific requirements for APGWamide research:

• The critical importance of C-terminal amidation (Wamide motif) for receptor activation

• Proper handling to maintain peptide stability during transit

• Appropriate reconstitution for various assay systems

• Storage conditions to prevent degradation

• Documentation requirements for research compliance

Quality You Can Trust

• Rigorous Testing: Every batch undergoes HPLC and MS analysis

• Documentation: Full COAs provided for complete traceability

• Consistency: Reliable quality batch after batch

Seamless Supply to the USA Market

Sourcing APGWamide peptide for sale from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.

• Fast Shipping: 5-7 business days to US addresses

• Cold-Chain Packaging: Temperature-controlled transit at -20°C for sensitive peptides

• Desiccant Protection: Double-sealed packaging to prevent moisture absorption

• Wholesale Programs: Dedicated support for small and large supply companies

• Customs Expertise: Smooth clearance with complete documentation

• Discreet Packaging: Professional, temperature-controlled containers

• Tracking Integration: Real-time visibility from Shanghai to your lab

Research Applications: Where APGWamide Excels

Understanding the diverse applications of APGWamide helps researchers appreciate why quality matters.

Neuroscience and Neurophysiology

• Inhibitory Neurotransmitter Studies: Potassium channel activation and neuronal hyperpolarization

• Receptor Pharmacology: Three distinct APGWamide receptors with varying affinities

• Synaptic Transmission: Modulation of neuronal circuits in central nervous system

• Calcium Dynamics: GPCR-mediated signaling pathways

Reproductive Biology

• Penis Morphogenic Factor (PMF): Initial growth of male accessory sex organs in gastropods

• Imposex Research: Endocrine disruption mechanisms following tributyltin (TBT) exposure

• Mating Behavior: Control of male reproductive activity

• Vas Deferens Modulation: Works antagonistically with conopressin

Developmental Biology

• Sexual Differentiation: Organogenesis of male reproductive structures

• Juvenile Development: Gene expression detected in non-copulating juveniles

• Accessory Sex Organ Growth: Androgenic steroid feedback mechanisms

Muscle Physiology

• Myogenic Activity: Modulation of molluscan muscle contraction

• GW-amide Effects: C-terminal dipeptide fragment shows potent modulatory actions

• Presynaptic Actions: Acts on presynaptic sites in molluscan muscles

Comparative Neurobiology

• Evolutionary Conservation: Wamide peptides are ancestral signaling systems in eumetazoans

• Cross-Species Analysis: Present in gastropods, bivalves, and cephalopods

• Phylogenetic Studies: Understanding neuropeptide evolution

 Questions

: What exactly is APGWamide peptide for sale at Apeptide?
A: APGWamide (Ala-Pro-Gly-Trp-NH₂) is a synthetic tetrapeptide neuropeptide first identified in molluscan ganglia . It functions as an inhibitory neurotransmitter and is implicated in reproductive development. It is supplied for laboratory investigation and in vitro research only, not for human consumption. Our APGWamide is manufactured at our Shanghai facility with 99% purity verification.

: What purity levels do you guarantee for APGWamide?
A: We guarantee 99% purity, verified by HPLC testing with Certificates of Analysis available for every batch. Each COA provides detailed purity analysis, mass spectrometry confirmation (428.48 g/mol expected), and batch-specific data .

: What is the CAS number for APGWamide?
A: The CAS number for APGWamide is 126675-52-3 .

: Is your APGWamide for human consumption?
A: Absolutely not. Our APGWamide is strictly for research and laboratory use only. It is not for human consumption, clinical application, or any use involving humans or animals. All products are labeled “FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE” .

: How should I store APGWamide upon receipt?
A: APGWamide should be stored at -20°C (freezer) immediately upon receipt, protected from light and moisture . Lyophilized powder is stable when stored properly. Avoid repeated freeze-thaw cycles.

: What solvent should I use for reconstitution?
A: APGWamide is soluble in aqueous buffers. The TFA salt form generally enhances solubility in aqueous solutions . For most applications, sterile water, PBS (pH 7.4), or artificial seawater (for marine species studies ) is appropriate. Contact our technical team for application-specific recommendations.  apgwamide peptide for sale

: What is the molecular weight of APGWamide?
A: The molecular weight is 428.48 g/mol .

: Why is C-terminal amidation important?
A: The Wamide motif (Trp-NH₂) at the C-terminus is essential for receptor activity in APGWamide signaling systems . Peptide analogs without proper amidation show little or no biological activity.

: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States.

: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through shanghaiapeptides.com with your volume requirements.

: What documentation do you provide?
A: Every order includes batch-specific Certificates of Analysis (COAs) with HPLC and MS data. We also provide commercial invoices, packing lists, and customs documentation as needed.

: What research has been published on APGWamide?
A: APGWamide has been extensively studied and published in peer-reviewed journals including the Journal of Neuroscience , Peptides , ACS Chemical Neuroscience , and the Journal of Comparative Neurology . Research spans neurobiology, reproductive biology, and comparative physiology.  apgwamide peptide for sale

 The Apeptide Standard

Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards.

Analytical Methods

• HPLC Analysis: Every batch tested for purity (typically 99%+)

• Mass Spectrometry: ESI-MS or MALDI-TOF for molecular weight confirmation (428.48 Da expected)

• Amino Acid Analysis: Sequence verification (Ala-Pro-Gly-Trp)

• C-Terminal Amidation Confirmation: Essential for biological activity

• Peptide Content Determination: Accurate net peptide weight (>80% typical)

• Counterion Analysis: TFA salt content specified

• Endotoxin Testing: LAL assay for cell culture applications

• Stability Studies: Ensuring integrity under various conditions

Batch Documentation

Each shipment includes:

• Certificate of Analysis with actual test results

• HPLC chromatogram (available upon request)

• Mass spectrometry data

• Batch number for traceability

• Expiration date and storage recommendations

• Reconstitution guidelines

 A Complete Research Partner

Apeptide (Shanghai) Co., Ltd. is more than just a supplier of APGWamide peptide for sale. We are a full-service biochemical manufacturer committed to advancing research worldwide.

Our Capabilities

• Custom Synthesis: Develop proprietary peptides for your specific research needs

• Catalog Peptides: Hundreds of sequences available for immediate shipment

• Neuropeptide Library: Comprehensive collection including Wamide family peptides

• Fluorescent Dyes: High-purity labeling agents for imaging and detection

• Amino Acids: Building blocks for synthesis and research

Quality Certifications and Compliance

• Licensed manufacturer with physical facility in Pudong District, Shanghai

• Rigorous quality control protocols

• Transparent documentation and traceability

• Experienced technical support team

• Strict adherence to research-use-only compliance

The Science Behind APGWamide

APGWamide’s mechanism of action has been well-characterized over three decades of research. It functions as an inhibitory neurotransmitter by increasing membrane permeability to potassium ions (K⁺), leading to neuronal hyperpolarization and reduced excitability .

Recent advances have identified three distinct receptors for APGWamide in Aplysia (APGWa-R1, APGWa-R2, and APGWa-R3) with EC₅₀ values of 45 nM, 2100 nM, and 2600 nM, respectively . These receptors are G-protein coupled receptors that activate specific signaling cascades. The Wamide motif at the C-terminus is essential for receptor activity, and alanine substitution experiments demonstrate that this motif is necessary for receptor activation .

The APGWamide precursor protein is notably efficient—in Lymnaea stagnalis, a single 219-amino acid preprohormone contains 10 copies of APGWamide-related peptides . Similarly, in Aplysia, the precursor generates nine copies of APGWamide, five connecting peptide sequences, and a C-terminal peptide .

The search for premium “APGWamide peptide for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need APGWamide for inhibitory neurotransmission studies, reproductive biology research, receptor characterization, or comparative neurobiology investigations, we are your trusted manufacturing partner.  apgwamide peptide for sale