mots-c peptide for sale

 Premium MOTS-c Peptide for Sale – Direct from Shanghai Manufacturer

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) represents a revolutionary class of signaling molecules in modern biomedical research. As a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome itself, MOTS-c has emerged as a critical tool for researchers investigating metabolic regulation, cellular stress response, aging, and mitochondrial-nuclear communication . If you are searching for “MOTS-c peptide for sale” for your laboratory investigations, you need a manufacturing partner who understands the significance of this 16-amino acid peptide and can deliver the purity your studies demand. That partner is Apeptide (Shanghai) Co., Ltd.

We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, catalog peptides, fluorescent dyes, and amino acids. When you purchase MOTS-c peptide for sale from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller.  mots-c peptide for sale

Understanding MOTS-c: The Mitochondrial-Encoded Signaling Peptide

MOTS-c is a 16-amino acid peptide encoded by the mitochondrial 12S rRNA region, making it unique among peptides as it originates from the mitochondrial genome rather than nuclear DNA . During metabolic stress—such as serum or glucose deprivation or oxidative stress—MOTS-c translocates to the nucleus in an AMPK-dependent manner, where it binds to the transcription factor NRF2 and activates anti-oxidative stress genes .

Key Characteristics

• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂ · C₂HF₃O₂ (TFA salt)

• Molecular Weight: 2174.6 Da (base), 2234.64 Da (acetate salt)

• CAS Number: 1627580-64-6

• PubChem CID: 50064302 (reference for related neuropeptides)

• Form: Lyophilized powder

• Purity: ≥99% (verified by HPLC)

• Appearance: White to off-white lyophilized powder

Mechanism of Action

MOTS-c exerts its effects through multiple interconnected pathways:

Why MOTS-c Matters in Research

MOTS-c has been the subject of intensive investigation across multiple research domains. Its levels decrease with age in humans, suggesting a potential role in the aging process . A comprehensive 2025 review in Life Sciences systematically analyzed the associations of MOTS-c with T2DM risk factors and its protective potential in diabetic cardiomyopathy .

Key Research Applications

Scientists seek MOTS-c peptide for sale for various laboratory investigations:

The Critical Importance of Quality for MOTS-c Research

When you purchase MOTS-c peptide for sale, quality parameters are non-negotiable. MOTS-c is a 16-amino acid peptide that requires precise synthesis to ensure correct sequence and full biological activity. Low-quality materials may contain truncations, racemization, or impurities that completely invalidate research results.

 Apeptide Quality Standard

• 99% Purity Guarantee: Verified by High-Performance Liquid Chromatography (HPLC)

• Mass Spectrometry: Molecular weight confirmation (2174.6 Da expected)

• Amino Acid Analysis: Sequence verification (MRWQEMGYIFYPRKLR)

• Peptide Content Determination: Accurate net peptide weight

• Counterion Analysis: Acetate or TFA content specified (affects solubility)

• Endotoxin Testing: <0.05 EU/mg available for cell culture applications

• Residual Solvents: Meets ICH guidelines (Acetonitrile ≤0.041%, Methanol ≤0.3%)

• Batch-Specific COAs: Full traceability with Certificates of Analysis

• Stability Testing: Stable for at least 1 year at -20°C ; ensure integrity from our lab to yours

Why Purity Matters Specifically for MOTS-c Research

• Metabolic Studies: AMPK activation and glucose uptake assays are highly sensitive to impurities

• Nuclear Translocation Assays: Confocal imaging and transcription factor binding require pure material

• In Vivo Studies: Dosing consistency critical for metabolic and aging research

• Mechanistic Studies: Pathway analysis demands documented purity

The Manufacturer Advantage: Why Source MOTS-c from Apeptide

When you search for “MOTS-c peptide for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice.

Complete Transparency

• Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.

• Manufacturing Expertise: Decades of combined experience in peptide synthesis and biochemical production.

• No Middlemen: You pay manufacturer-direct pricing, not reseller markups.

Technical Expertise

Our team understands the specific requirements for MOTS-c research:

• Proper handling to maintain peptide stability during transit

• Appropriate reconstitution for various assay systems

• Storage conditions to prevent degradation (stable 1 year at -20°C)

• Documentation requirements for research compliance

Quality You Can Trust

• Rigorous Testing: Every batch undergoes HPLC and MS analysis

• Documentation: Full COAs provided for complete traceability

• Consistency: Reliable quality batch after batch

Seamless Supply to the USA Market

Sourcing MOTS-c peptide for sale from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.

• Fast Shipping: 5-7 business days to US addresses

• Cold-Chain Packaging: Temperature-controlled transit at -20°C for sensitive peptides

• Desiccant Protection: Double-sealed packaging to prevent moisture absorption

• Wholesale Programs: Dedicated support for small and large supply companies

• Customs Expertise: Smooth clearance with complete documentation

• Discreet Packaging: Professional, temperature-controlled containers

• Tracking Integration: Real-time visibility from Shanghai to your lab

 MOTS-c Excels

Understanding the diverse applications of MOTS-c helps researchers appreciate why quality matters.

Metabolic Disease Research

• Type 2 Diabetes: Investigating glucose homeostasis, insulin sensitivity, and β-cell function

• Obesity Studies: Energy expenditure, lipid metabolism, and diet-induced obesity models

• Diabetic Cardiomyopathy: Cardiac protection and metabolic regulation

Mitochondrial Biology

• Mitochondrial-Nuclear Communication: Retrograde signaling pathways

• Mitochondrial Biogenesis: AMPK/PGC-1α pathway activation

• Stress Response: Metabolic stress (glucose/serum deprivation, oxidative stress)

Aging Research

• Age-Related Decline: MOTS-c levels decrease with age

• Lifespan Studies: Extension of healthspan and lifespan in model organisms

• Age-Related Diseases: Diabetes, cardiovascular disease, neurodegeneration

Cardiovascular Research

• Diabetic Cardiomyopathy: Protective effects and therapeutic potential

• Cardiovascular Disease: Emerging applications under investigation

Neurobiology

• Neuroprotection: Blood-brain barrier penetration; anti-oxidative stress effects

• Traumatic Brain Injury: Investigational applications

• Neurodegeneration: Age-related cognitive decline

Inflammation and Immunology

• NF-κB Pathway Inhibition: Reduces inflammatory signaling

• Systemic Inflammation: Potential therapeutic applications

Pulmonary Research

• Pulmonary Fibrosis: Anti-fibrotic potential; improves cellular homeostasis

• Lung Disease: Emerging research applications

Exercise Physiology

• Exercise Mimetic: Investigated as potential exercise mimetic

• Skeletal Muscle: Improves glucose metabolism in muscle tissue

• Physical Endurance: Performance-related research

Frequently Asked Questions

: What exactly is MOTS-c peptide for sale at Apeptide?
A: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide encoded by the mitochondrial genome . It plays a key role in metabolic regulation, stress response, and mitochondrial-nuclear communication . It is supplied for laboratory investigation and in vitro research only, not for human consumption. Our MOTS-c is manufactured at our Shanghai facility with 99% purity verification.

: What purity levels do you guarantee for MOTS-c?
A: We guarantee 99% purity, verified by HPLC testing with Certificates of Analysis available for every batch. Each COA provides detailed purity analysis, mass spectrometry confirmation (2174.6 Da expected), and batch-specific data .

: What is the CAS number for MOTS-c?
A: The CAS number for MOTS-c is 1627580-64-6 .

: Is your MOTS-c for human consumption?
A: Absolutely not. Our MOTS-c is strictly for research and laboratory use only. It is not for human consumption, clinical application, or any use involving humans or animals . All products are labeled “FOR RESEARCH USE ONLY.”

: How should I store MOTS-c upon receipt?
A: MOTS-c should be stored at -20°C (freezer) immediately upon receipt, protected from light and moisture. It is stable for at least 1 year when stored properly at -20°C . Some suppliers recommend -80°C for extended storage . Avoid repeated freeze-thaw cycles. For long-term storage, aliquot and store at -80°C .

: How should I reconstitute MOTS-c?
A: It is recommended to reconstitute lyophilized MOTS-c in sterile 18MΩ-cm H₂O at not less than 100 µg/ml, which can then be further diluted into other aqueous solutions . Do not vortex . For long-term storage after reconstitution, adding a carrier protein (0.1% HSA or BSA) is recommended . Reconstituted solutions can be stored at 4°C for 2-7 days .

: What is the molecular weight of MOTS-c?
A: The molecular weight is approximately 2174.6 Da for the base peptide , 2234.64 Da for the acetate salt .

: Does MOTS-c cross the blood-brain barrier?
A: Yes, research indicates that MOTS-c (human) acetate is a blood-brain barrier-penetrating peptide .

: What are the primary research applications for MOTS-c?
A: MOTS-c is investigated for type 2 diabetes, insulin sensitivity, obesity, aging, mitochondrial function, cardiovascular disease, neuroprotection, inflammation, pulmonary fibrosis, and as a potential exercise mimetic .

: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States.   mots-c peptide for sale

: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through shanghaiapeptides.com with your volume requirements.

: What documentation do you provide?
A: Every order includes batch-specific Certificates of Analysis (COAs) with HPLC and MS data. We also provide commercial invoices, packing lists, and customs documentation as needed.

The Apeptide Standard

Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards.

Analytical Methods

• HPLC Analysis: Every batch tested for purity (typically 99%+)

• Mass Spectrometry: ESI-MS or MALDI-TOF for molecular weight confirmation (2174.6 Da expected)

• Amino Acid Analysis: Sequence verification (MRWQEMGYIFYPRKLR)

• Peptide Content Determination: Accurate net peptide weight

• Counterion Analysis: Acetate or TFA content specified

• Endotoxin Testing: <0.05 EU/mg available for cell culture applications

• Residual Solvents: Acetonitrile ≤0.041%, Methanol ≤0.3%

• Water Content: ≤5.0% by Karl Fischer

• Stability Studies: Ensuring integrity under various conditions

Batch Documentation

Each shipment includes:

• Certificate of Analysis with actual test results

• HPLC chromatogram (available upon request)

• Mass spectrometry data

• Batch number for traceability

• Expiration date and storage recommendations

• Reconstitution guidelines

 Complete Research Partner

Apeptide (Shanghai) Co., Ltd. is more than just a supplier of MOTS-c peptide for sale. We are a full-service biochemical manufacturer committed to advancing research worldwide.

Our Capabilities

• Custom Synthesis: Develop proprietary peptides for your specific research needs

• Catalog Peptides: Hundreds of sequences available for immediate shipment

• Mitochondrial Peptide Library: Including MOTS-c, Humanin, and related mitochondrial-derived peptides

• Fluorescent Dyes: High-purity labeling agents for imaging and detection

• Amino Acids: Building blocks for synthesis and research

Quality Certifications and Compliance

• Licensed manufacturer with physical facility in Pudong District, Shanghai

• Rigorous quality control protocols

• Transparent documentation and traceability

• Experienced technical support team

• Strict adherence to research-use-only compliance

The Science Behind MOTS-c

MOTS-c’s mechanism of action has been elucidated through extensive research over the past decade. It was discovered as part of a family of mitochondrial-derived peptides (MDPs) that also includes Humanin and SHLP1-6 . During metabolic stress—such as serum or glucose deprivation or oxidative stress—MOTS-c translocates to the nucleus in an AMPK-dependent manner, where it binds to the transcription factor NRF2 and activates anti-oxidative stress genes .

The peptide promotes biosynthesis of the endogenous AMP analog AICAR, leading to AMP-activated protein kinase (AMPK) activation . This induces cellular and systemic glucose uptake and improves insulin sensitivity . Preclinical studies have shown that MOTS-c prevents diet-induced obesity (DIO) in mice .

The search for premium “MOTS-c peptide for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need MOTS-c for metabolic disease research, aging studies, mitochondrial biology, neuroprotection, or specialized investigations, we are your trusted manufacturing partner.  mots-c peptide for sale