L-R4W2 Research Peptide for Sale | Shanghai Apeptide

Welcome to Shanghai Apeptide Co., Ltd., your definitive source for premium l-r4w2 research peptide for sale. If you are a researcher or a supply company in the USA seeking a reliable, wholesale partner, you have found it. As an authentic, licensed manufacturer headquartered in Shanghai, China, we bridge the gap between advanced peptide synthesis and your laboratory’s precise requirements.

Our foundation of quality is built at our primary physical location: No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. From this advanced facility, we oversee all peptide synthesis operations, ensuring that every shipment of l-r4w2 research peptide meets our unwavering 99% purity standard. We invite you to explore our comprehensive range and discover the Apeptide difference.  l-r4w2 research peptide for sale

What is L-R4W2? Understanding This Specialized Research Peptide

L-R4W2 is a synthetic arginine-rich hexapeptide with the sequence RRRRWW-NH₂ (single-letter code) or H-Arg-Arg-Arg-Arg-Trp-Trp-NH₂ (three-letter code) . It is a potent and stereoselective antagonist of the vanilloid receptor 1, more commonly known as the TRPV1 (transient receptor potential vanilloid 1) channel . With a molecular formula of C₄₆H₇₁N₂₁O₆ and a molecular weight of approximately 1014.2 Da, this peptide is designed specifically for advanced pain signaling research .

Scientists study L-R4W2 for its key roles in:

• TRPV1 Antagonism: It potently blocks the TRPV1 receptor, a non-selective cation channel widely distributed on sensory nerve endings that integrates various painful stimuli .

• Pain Pathway Research: By inhibiting TRPV1 activation, it reduces pain signal transmission, making it a valuable tool for studying nociception and developing novel analgesic strategies .  l-r4w2 research peptide for sale

• Calcium Flux Studies: It blocks TRPV1-mediated calcium currents in dorsal root ganglion neurons, allowing researchers to investigate calcium signaling in pain pathways .

• Stereoselectivity Investigations: The L-enantiomer form demonstrates significantly higher potency than its D-enantiomer counterpart, providing insights into receptor-ligand interactions .

It is essential to state clearly: L-R4W2 research peptide is supplied strictly for research and laboratory use only. It is not for human consumption or medical application.

The Science Behind L-R4W2: A Research Overview

L-R4W2 has emerged as a highly selective tool for studying TRPV1 receptor pharmacology, with research demonstrating its superiority over traditional antagonists like capsazepine .  l-r4w2 research peptide for sale

 How Does L-R4W2 Work?

L-R4W2 exerts its effects by specifically targeting the TRPV1 receptor, a key integrator of painful stimuli. Its primary research-relevant actions include:

1. TRPV1 Receptor Binding: It binds to the vanilloid receptor 1 (VR1/TRPV1) with high affinity, acting as a competitive antagonist . The half-maximal inhibitory concentration (IC₅₀) is approximately 0.1 μM, demonstrating potent activity .

2. Inhibition of Calcium Influx: When TRPV1 is activated by stimuli such as capsaicin, resiniferatoxin (RTX), noxious heat, or acidic pH, it allows calcium ions to flow into neurons. L-R4W2 blocks this calcium influx, preventing neuronal excitation .

3. Stereoselective Antagonism: Research in native adult rat dorsal root ganglion neurons demonstrated that L-R4W2 antagonizes TRPV1-mediated effects with significantly higher potency than D-R4W2 or capsazepine. Apparent dissociation constants of 4.0 nM (against RTX) and 3.7 nM (against capsaicin) were observed . l-r4w2 research peptide for sale

Key Research Context and Resources

• Pain Research Applications: TRPV1 is a well-validated target for analgesic development. L-R4W2 provides researchers with a potent tool to study pain mechanisms without the limitations of earlier antagonists . This research has implications for inflammatory pain, neuropathic pain, and certain types of cancer pain .

• Authoritative Scientific Literature: The foundational research on L-R4W2 was published in the Journal of Pharmacology and Experimental Therapeutics and is indexed on , a key resource from the National Institutes of Health (NIH) . This peer-reviewed work established the peptide’s mechanism and potency, underscoring the need for high-purity material for reproducible results .

Why Choose Shanghai Apeptide for Your Research Needs?

When your experiments depend on accuracy and consistency, your choice of supplier is paramount. Here is why leading labs choose us for l-r4w2 peptide supply.

1. Uncompromising Quality and 99% Purity

We are the manufacturer, not a distributor. Our synthesis facility in the Pudong District of Shanghai is dedicated to producing research peptides of the highest caliber. Every batch of our l-r4w2 research peptide is synthesized and purified to achieve 99% purity. This guarantees your experimental data reflects the true properties of the compound, free from confounding impurities.

2. Direct Manufacturer-Direct Pricing

By sourcing directly from Shanghai Apeptide Co., Ltd., you eliminate supply chain markups. This means you acquire premium, licensed products at genuinely competitive wholesale prices. This makes us the ideal partner for both small, specialized labs and large-scale US-based supply companies.  l-r4w2 research peptide for sale

3. Specialized Expertise in Peptide Chemistry

Our core mission is the research, development, and manufacture of biochemicals, with a deep focus on peptides, fluorescent dyes, and amino acids. This specialization ensures we understand your need for consistency, proper documentation, and technical support. Trust that your order of L-R4W2 for sale is handled with expert care.

Committed to Global Research Standards

Our manufacturing philosophy aligns with the expectations of the international scientific community. For researchers seeking deeper insights into L-R4W2 and its applications, resources like the National Institutes of Health (NIH) offer extensive, peer-reviewed data via PubMed . Broader discussions on pain research methodologies and TRPV1 pharmacology can also be found on professional platforms like Medium and in journals available through ScienceDirect . These resources all underscore the same principle: valid science requires high-quality, reliable materials.

For a broader view of our quality standards, explore our detailed product page on  . You can also review the specifications for , another advanced research compound in our catalog  l-r4w2 research peptide for sale

Frequently Asked Questions About L-R4W2 Peptide

1: Is this L-R4W2 peptide for human consumption?
No. Absolutely not. Shanghai Apeptide Co., Ltd. supplies l-r4w2 research peptide for sale strictly for research and laboratory purposes only. It is not approved or intended for human consumption, medical use, or veterinary application .

2: What purity level do you guarantee for L-R4W2?
We specialize in Premium High Quality 99% Purity Peptides. Our L-R4W2 is rigorously synthesized and tested to meet this high standard consistently, ensuring reliability for your sensitive research protocols.    l-r4w2 research peptide for sale

3: What is the sequence and molecular weight of L-R4W2?
L-R4W2 has the sequence H-Arg-Arg-Arg-Arg-Trp-Trp-NH₂ (single-letter: RRRRWW-NH₂) with a molecular formula of C₄₆H₇₁N₂₁O₆ and a molecular weight of approximately 1014.2 Da .

4: Can I order L-R4W2 in bulk for my supply company?
Yes, we are a dedicated wholesale supplier. We welcome inquiries and orders of all sizes. Visit our shop to see our product range and contact our team for customized bulk pricing.

5: How should L-R4W2 peptide be stored for research?
For optimal stability, L-R4W2 (typically supplied as a lyophilized powder) should be stored at -20°C for long-term storage, protected from light and moisture. Short-term storage at 2-8°C is acceptable . Please refer to the Certificate of Analysis (CoA) included with your order for specific storage guidelines.

6: Are you a legitimate, licensed manufacturer based in China?
Yes. Shanghai Apeptide Co., Ltd. is a professional, authentic manufacturer. Our headquarters and peptide synthesis operations are located at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. We are fully dedicated to the compliant research, development, and marketing of diverse biochemical products.

Ready to Source Premium L-R4W2 for Your Research?

Do not compromise on the quality of your critical research materials. As a premier peptide manufacturer in China, Shanghai Apeptide is your direct, reliable source for the high-purity raw materials you need to advance discovery in pain signaling and TRPV1 research.

Whether you need a small quantity for a specific study or a consistent wholesale supply for your business, our team is ready to support you. Experience the confidence of working with a trusted, licensed supplier.   l-r4w2 research peptide for sale