melanotan 2 peptide for sale

: Premium Melanotan 2 Peptide for Sale – Direct from Shanghai Manufacturer

Melanotan II (MT-II) represents a significant milestone in synthetic peptide development. As a potent, cyclic analog of alpha-melanocyte stimulating hormone (α-MSH), this peptide has been a valuable research tool for scientists investigating melanocortin receptors, pigmentation biology, and receptor pharmacology for decades . If you are searching for “Melanotan 2 peptide for sale,” you need a manufacturing partner who understands the complexity of this cyclic heptapeptide and can deliver the purity your research demands. That partner is Apeptide (Shanghai) Co., Ltd.

We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, including Melanotan II and related biochemicals. When you purchase Melanotan 2 peptide for sale from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller.

Understanding Melanotan 2: The Synthetic α-MSH Analog

Melanotan II is a synthetic cyclic heptapeptide analog of α-melanocyte stimulating hormone (α-MSH), developed at the University of Arizona specifically as a research tool for studying melanocortin receptors . Unlike the linear native hormone, MT-II incorporates a lactam bridge that confers conformational constraint and enhanced metabolic stability.

Key Characteristics

• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂

• Molecular Formula: C₅₀H₆₉N₁₅O₉

• Molecular Weight: 1024.2 Daltons

• CAS Number: 121062-08-6

• Structure: Cyclic heptapeptide with C-terminal amidation

Receptor Pharmacology

Melanotan II is a potent but non-selective agonist of human melanocortin receptors (hMCRs), activating:

• MC1R: Primarily expressed on melanocytes; involved in pigmentation

• MC3R: Expressed in the brain and peripheral tissues

• MC4R: Centrally expressed; involved in energy homeostasis

• MC5R: Widely expressed with diverse functions

This broad receptor activity makes MT-II a valuable pharmacological tool but also underscores the need for careful interpretation in research settings .

Why Melanotan 2 Matters in Research

Melanotan II has been the subject of extensive investigation since its development in the 1990s .

Key Research Applications

Scientists seek Melanotan 2 peptide for sale for various laboratory investigations:

Melanocortin Receptor Pharmacology:

• Receptor binding and activation studies

• Structure-activity relationship investigations

• Understanding agonist selectivity and bias

• G-protein coupled receptor signaling pathways

Pigmentation Biology:

• Melanogenesis mechanisms

• MC1R-mediated signaling

• Pigment cell biology

• Ultraviolet radiation response pathways

Historical Clinical Investigation:
MT-II was evaluated in pilot Phase I clinical studies in the 1990s, where it demonstrated tanning activity after only five low-dose subcutaneous injections . Researchers studying these historical trials use MT-II to understand:

• Early-stage peptide drug development

• Pharmacokinetic and pharmacodynamic relationships

• Dose-response relationships in humans

Peptide Chemistry:
As a model cyclic peptide, MT-II serves as a scaffold for:

• Novel cyclization strategies

• Conformation-activity relationship studies

• Drug design and optimization

Important Research Context:
While early clinical studies were conducted, clinical development of Melanotan II ceased in 2003, and no products containing this peptide have received FDA approval . Current research use focuses on basic science applications, not clinical development.

Regulatory and Compliance Considerations

Researchers must be aware of the current regulatory landscape surrounding Melanotan II.

Current Status

• FDA Category 2 Substance: As of 2026, the FDA has identified Melanotan II as a substance posing significant safety risks, effectively removing it from the list of substances eligible for traditional compounding

• No FDA Approval: No Melanotan II products are FDA-approved

• Research Use Only: Strictly for laboratory investigation, not for human consumption

Compliance Requirements

Apeptide (Shanghai) Co., Ltd. supplies Melanotan II strictly for research purposes. All products are:

• Labeled “For Research Use Only. Not for human use.”

• Shipped with appropriate documentation for research compliance

• Intended for qualified research institutions and laboratories

The Critical Importance of Quality for Melanotan 2

Melanotan II is a cyclic peptide requiring precise synthesis to ensure correct cyclization, proper disulfide bridging (where applicable), and C-terminal amidation—all essential for biological activity. Low-quality materials may lack proper cyclization, contain truncated sequences, or have incorrect stereochemistry that completely alters receptor interactions.

The Apeptide Quality Standard

• 99% Purity Guarantee: Verified by HPLC and Mass Spectrometry

• Correct Cyclization Confirmation: Ensuring proper lactam bridge formation

• C-Terminal Amidation Verification: Essential for bioactivity

• Batch-Specific COAs: Full traceability with Certificates of Analysis

• Stability Testing: Maintaining integrity from our lab to yours

• Endotoxin Testing: Available for cell culture applications

Our Melanotan 2 and Related Product Portfolio

Apeptide (Shanghai) Co., Ltd. manufactures high-purity Melanotan II alongside a comprehensive range of research peptides and biochemicals.

Melanotan 2 Offerings

• Melanotan II (Standard): The complete cyclic heptapeptide with confirmed lactam bridge

• Melanotan II Analogs: Related sequences for structure-activity studies

• Labeled Melanotan II: Fluorescently tagged versions for imaging and localization studies

Complementary Research Products

• Other Melanocortin Peptides: α-MSH, Melanotan I, and selective analogs

• Melanocortin Receptor Tools: Antagonists and selective agonists

• Catalog Peptides: Hundreds of research-grade sequences ready for immediate shipment

• Fluorescent Dyes & Amino Acids: For custom labeling and synthesis needs

The Manufacturer Advantage: Why Source Melanotan 2 from Apeptide

When you search for “Melanotan 2 peptide for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice.

Complete Transparency

• Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.

• Manufacturing Expertise: Decades of combined experience in peptide synthesis and biochemical production.

• No Middlemen: You pay manufacturer-direct pricing, not reseller markups.

Technical Expertise

Melanotan II requires specialized knowledge. Our team understands:

• The critical importance of correct cyclization for receptor binding

• The role of D-Phe stereochemistry in biological activity

• The distinction between research use and clinical application

• Proper handling to maintain peptide integrity

• Appropriate reconstitution for various assay systems

Quality You Can Trust

• Rigorous Testing: Every batch undergoes HPLC and MS analysis

• Documentation: Full COAs provided for complete traceability

• Consistency: Reliable quality batch after batch

Seamless Supply to the USA Market

Sourcing Melanotan 2 peptide for sale from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.

• Fast Shipping: 5-7 business days to US addresses

• Cold-Chain Packaging: Temperature-controlled transit for sensitive peptides

• Wholesale Programs: Dedicated support for small and large supply companies

• Customs Expertise: Smooth clearance with complete documentation

• Discreet Packaging: Professional, temperature-controlled containers

Research Applications: Where Melanotan 2 Excels

Understanding the diverse applications of Melanotan II helps researchers appreciate why quality matters.

Melanocortin Receptor Studies

MT-II serves as a tool for investigating:

• Receptor binding kinetics and thermodynamics

• Agonist-induced signaling pathways

• Constitutive receptor activity

• Allosteric modulation mechanisms

Peptide Drug Design

As a conformationally constrained peptide, MT-II provides insights into:

• Cyclization strategies for metabolic stability

• Structure-based drug design

• Peptide-receptor interactions at the molecular level

• Development of receptor-selective analogs

Pigment Cell Biology

Researchers use MT-II to study:

• Melanin synthesis pathways

• Tyrosinase activation mechanisms

• Melanocyte differentiation

• Paracrine signaling in skin

Historical Research Context

MT-II’s development history offers valuable lessons in:

• Early-stage peptide drug development

• Translation from preclinical to clinical investigation

• Pharmacokinetic optimization

Frequently Asked Questions

: Are your Melanotan 2 peptide for sale products approved for human use?
A: No. Apeptide (Shanghai) Co., Ltd. supplies products strictly for research and development purposes. They are not for human consumption, clinical application, or any use involving humans or animals . Clinical development of Melanotan II ceased in 2003, and no products are FDA-approved . This distinction is critical for compliance .

: What is the difference between Melanotan I and Melanotan II?
A: Melanotan I (afamelanotide) is a linear peptide, while Melanotan II is a cyclic peptide with a lactam bridge. This cyclization confers different conformational properties and receptor interaction profiles. MT-II is also non-selective across melanocortin receptors, while some analogs have been developed for selectivity .

: What receptors does Melanotan II activate?
A: Melanotan II is a potent but non-selective agonist of melanocortin receptors MC1R, MC3R, MC4R, and MC5R .

: How do I verify the purity of your Melanotan 2?
A: We provide a Certificate of Analysis (COA) via HPLC and Mass Spectrometry testing for every batch. You can request this before or after purchase through our website.

: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States.

: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through  with your volume requirements.

: How should I store Melanotan 2 upon receipt?
A: Melanotan II should be stored lyophilized, desiccated, at -20°C (freezer) immediately upon receipt, protected from light . Lyophilized powder is stable when stored properly. Avoid repeated freeze-thaw cycles. Reconstituted solutions should be stored at 4°C for short-term use (2-7 days) or frozen for longer storage .

: What solvent should I use for reconstitution?
A: It is recommended to reconstitute lyophilized Melanotan II in sterile 18MΩ H₂O at not less than 100 µg/ml, which can then be further diluted into other aqueous solutions . For long-term storage after reconstitution, adding a carrier protein (0.1% HSA or BSA) is recommended .

: What is the molecular formula and weight of Melanotan II?
A: The molecular formula is C₅₀H₆₉N₁₅O₉, and the molecular weight is 1024.2 Daltons .

: Is Melanotan II FDA approved?
A: No. Clinical development of Melanotan II ceased in 2003, and no Melanotan II products have received FDA approval . The FDA has classified it as a Category 2 substance with significant safety risks .

 The Apeptide Standard

Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards.

• HPLC Analysis: Every batch tested for purity (typically 99%+)

• Mass Spectrometry: Molecular weight confirmation

• Cyclization Confirmation: Ensuring proper lactam bridge formation

• Amino Acid Analysis: Sequence verification including D-Phe configuration

• Peptide Content Determination: Accurate net peptide weight

• Endotoxin Testing: Available for sensitive applications

• Stability Studies: Ensuring integrity under various conditions

Beyond Melanotan 2: A Complete Research Partner

Apeptide (Shanghai) Co., Ltd. is more than just a Melanotan II supplier. We are a full-service biochemical manufacturer committed to advancing research worldwide.

Our Capabilities

• Custom Synthesis: Develop proprietary peptides for your specific research needs

• Catalog Peptides: Hundreds of sequences available for immediate shipment

• Melanocortin Peptide Library: Comprehensive collection of melanocortin receptor ligands

• Fluorescent Dyes: High-purity labeling agents for imaging and detection

• Amino Acids: Building blocks for synthesis and research

Quality Certifications and Compliance

• Licensed manufacturer with physical facility in Pudong District, Shanghai

• Rigorous quality control protocols

• Transparent documentation and traceability

• Experienced technical support team

• Strict adherence to research-use-only compliance

The Science Behind Melanotan 2

Melanotan II was specifically designed as a conformationally constrained analog of α-MSH to investigate the structural requirements for melanocortin receptor activation . The incorporation of a lactam bridge between Asp⁵ and Lys¹⁰ creates a cyclic structure that stabilizes the bioactive conformation .

This cyclization strategy has proven influential in peptide drug design, demonstrating that conformational constraint can enhance receptor affinity and metabolic stability while providing insights into the three-dimensional requirements for receptor activation .

The peptide’s ability to activate multiple melanocortin receptor subtypes makes it a valuable pharmacological tool, while also highlighting the challenges of achieving receptor selectivity—a goal pursued through various analog development efforts .

The search for “Melanotan 2 peptide for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need Melanotan II for melanocortin receptor studies, peptide chemistry research, or pigmentation biology investigations, we are your trusted manufacturing partner.