Melanotan 1 Peptide for Sale – Direct from Shanghai Manufacturer
Melanotan 1 (Afamelanotide) represents a significant advancement in melanocortin research, offering scientists a potent and selective synthetic analog of alpha-melanocyte stimulating hormone (α-MSH) . This 13-amino acid linear peptide was specifically designed to stimulate melanogenesis through the melanocortin-1 receptor (MC1R), making it an invaluable research tool for scientists investigating pigmentation biology, melanocortin receptor pharmacology, and photoprotection mechanisms . If you are searching for “melanotan 1 peptide for sale” for your laboratory investigations, you need a manufacturing partner who understands the complexity of this melanocortin peptide and can deliver the purity your studies demand. That partner is Apeptide (Shanghai) Co., Ltd.
We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, catalog peptides, fluorescent dyes, and amino acids. When you purchase melanotan 1 peptide for sale from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller.melanotan 1 peptide for sale
Understanding Melanotan 1: The Synthetic α-MSH Analog
Melanotan 1 (Afamelanotide) is a synthetic 13-amino acid linear peptide analog of alpha-melanocyte stimulating hormone (α-MSH) with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂ . It was developed as a more stable and potent alternative to natural α-MSH for melanocortin receptor research . melanotan 1 peptide for sale
Key Characteristics
| Parameter | Specification |
|---|---|
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂ |
| Molecular Formula | C₇₈H₁₁₁N₂₁O₁₉ |
| Molecular Weight | Approximately 1,646.85 g/mol |
| CAS Number | 75921-69-8 |
| Form | Lyophilized powder |
| Purity | ≥99% (verified by HPLC) |
| Storage | -20°C, protected from light and moisture |
Melanotan 1 vs. Melanotan 2: Key Differences
| Feature | Melanotan 1 (Afamelanotide) | Melanotan 2 |
|---|---|---|
| Structure | Linear 13-amino acid peptide | Cyclic 7-amino acid peptide |
| Receptor Selectivity | Higher MC1R selectivity | Non-selective (MC1R, MC3R, MC4R, MC5R) |
| Primary Action | Melanogenesis (pigmentation) | Broad melanocortin receptor effects |
| Stability | Enhanced vs. α-MSH | High (cyclic structure) |
| Research Focus | Pigmentation, photoprotection | Receptor pharmacology, broader applications |
Why Melanotan 1 Matters in Research
Melanotan 1 was developed to overcome the limitations of natural α-MSH, which has a short half-life and limited stability . Its enhanced stability and MC1R selectivity make it a valuable research tool for pigmentation biology and photoprotection studies . melanotan 1 peptide for sale
Key Research Applications
| Research Area | Key Findings | Research Context |
|---|---|---|
| Melanocortin Receptor Pharmacology | Selective MC1R agonist; used to characterize MC1R signaling | Receptor binding, signal transduction |
| Pigmentation Biology | Stimulates melanogenesis in melanocytes; increases eumelanin production | Melanocyte biology, pigment research |
| Photoprotection Research | Induces melanin production that provides UV protection | Dermatology, UV damage prevention |
| MC1R Signaling | Activates cAMP pathway via MC1R; stimulates tyrosinase expression | Melanogenesis, enzyme regulation |
| Comparative Studies | Used to distinguish MC1R-mediated effects from other melanocortin receptors | Receptor selectivity, pharmacology |
| Erythropoietic Protoporphyria Research | Studied for its ability to increase melanin and provide photoprotection | Rare disease research, photodermatology |
Potent Research-Grade Activity
| Parameter | Value |
|---|---|
| MC1R EC₅₀ | Low nanomolar range |
| Melanin Production | Dose-dependent increase in melanocyte cultures |
| Stability | Enhanced resistance to enzymatic degradation vs. α-MSH |
| Half-Life | Extended compared to natural α-MSH |
The Critical Importance of Quality for Melanotan 1 Research
When you purchase melanotan 1 peptide for sale, quality parameters are non-negotiable. Melanotan 1 contains a D-phenylalanine residue and a C-terminal amidation that require precise synthesis for full biological activity . melanotan 1 peptide for sale
The Apeptide Quality Standard
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99% Purity Guarantee: Verified by High-Performance Liquid Chromatography (HPLC)
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Mass Spectrometry: Molecular weight confirmation (1,646.85 g/mol expected)
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Amino Acid Analysis: Sequence verification including D-Phe and Nle (norleucine)
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N-Terminal Acetylation Confirmation: Essential for stability and activity
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C-Terminal Amidation Confirmation: Essential for receptor binding
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Chiral Purity: Confirmation of D-Phe configuration
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
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Counterion Analysis: Acetate or TFA content specified
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Water Content: ≤8.0% by Karl Fischer
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Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Batch-Specific COAs: Full traceability with Certificates of Analysis
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Stability Testing: Ensuring integrity from our lab to yours
Why Purity Matters for Melanotan 1 Research
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Receptor Binding Studies: MC1R binding affinity requires pure material
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Melanocyte Assays: Impurities affect melanin production measurements
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In Vivo Studies: Dosing consistency critical for pigmentation studies
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Mechanistic Studies: Pathway analysis demands documented purity
The Manufacturer Advantage: Why Source Melanotan 1 from Apeptide
When you search for “melanotan 1 peptide for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice. melanotan 1 peptide for sale
Complete Transparency
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Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.
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Manufacturing Expertise: Decades of combined experience in peptide synthesis including D-amino acids.
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No Middlemen: You pay manufacturer-direct pricing, not reseller markups.
Technical Expertise
Our team understands the specific requirements for melanotan 1 research:
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Importance of D-Phe configuration for MC1R selectivity
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Role of N-terminal acetylation and C-terminal amidation
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Proper handling to maintain peptide stability
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Appropriate reconstitution for melanocyte assays
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Storage conditions to prevent degradation
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Documentation requirements for research compliance
Quality You Can Trust
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Rigorous Testing: Every batch undergoes HPLC and MS analysis
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Documentation: Full COAs provided for complete traceability
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Consistency: Reliable quality batch after batch
Seamless Supply to the USA Market
Sourcing melanotan 1 peptide for sale from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.
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Fast Shipping: 5-7 business days to US addresses
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Cold-Chain Packaging: Temperature-controlled transit at -20°C for sensitive peptides
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Desiccant Protection: Double-sealed packaging to prevent moisture absorption
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Wholesale Programs: Dedicated support for small and large supply companies
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Customs Expertise: Smooth clearance with complete documentation
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Tracking Integration: Real-time visibility from Shanghai to your lab
Research Applications: Where Melanotan 1 Excels
Understanding the diverse applications of melanotan 1 helps researchers appreciate why quality matters.
Melanocortin Receptor Research
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MC1R binding and activation studies
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cAMP signaling pathway analysis
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Receptor selectivity comparisons (MC1R vs. MC3R, MC4R, MC5R)
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Structure-activity relationship investigations
Pigmentation Biology
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Melanocyte culture models
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Tyrosinase activity assays
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Eumelanin vs. pheomelanin production
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Melanogenesis signaling pathways
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MITF (microphthalmia-associated transcription factor) regulation
Photoprotection Research
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UV-induced DNA damage protection
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Melanin as a natural sunscreen
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Reactive oxygen species (ROS) reduction
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Skin photobiology models
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UVB and UVA protection mechanisms
Dermatology Research
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Vitiligo and pigmentary disorder models
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Hypopigmentation studies
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Melanocyte transplantation research
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Skin pigmentation regulation
Receptor Pharmacology
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G-protein coupled receptor (GPCR) signaling
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MC1R internalization and trafficking
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Biased agonism investigations
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Comparative studies with α-MSH and other analogs
Frequently Asked Questions
: What exactly is melanotan 1 peptide for sale at Apeptide?
A: Melanotan 1 (Afamelanotide) is a synthetic 13-amino acid linear peptide analog of α-MSH. It is a selective MC1R agonist that stimulates melanogenesis. It is supplied strictly for laboratory investigation and in vitro research only, not for human consumption. melanotan 1 peptide for sale
: What purity levels do you guarantee for melanotan 1?
A: We guarantee 99% purity, verified by HPLC testing with Certificates of Analysis available for every batch. Each COA provides detailed purity analysis, mass spectrometry confirmation (1,646.85 g/mol expected), and batch-specific data. melanotan 1 peptide for sale
: What is the CAS number for melanotan 1?
A: The CAS number for melanotan 1 (Afamelanotide) is 75921-69-8 .
: What is the molecular weight of melanotan 1?
A: The molecular weight is approximately 1,646.85 g/mol .
: What is the difference between melanotan 1 and melanotan 2?
A: Melanotan 1 is a 13-amino acid linear peptide with higher selectivity for MC1R, primarily used for pigmentation research. Melanotan 2 is a cyclic 7-amino acid peptide that is non-selective across melanocortin receptors (MC1R, MC3R, MC4R, MC5R), used for broader receptor pharmacology studies . melanotan 1 peptide for sale
: What is the primary mechanism of melanotan 1?
A: Melanotan 1 activates the MC1R receptor on melanocytes, stimulating the cAMP pathway, which increases tyrosinase expression and activity, leading to increased melanin production . melanotan 1 peptide for sale
: Is your melanotan 1 for human consumption?
A: Absolutely not. Our melanotan 1 is strictly for research and laboratory use only. It is not for human consumption, clinical application, or any use involving humans or animals. Afamelanotide is an FDA-approved prescription drug (Scenesse®) and should only be used in approved clinical settings . All products are labeled “FOR RESEARCH USE ONLY.”
: How should I store melanotan 1 upon receipt?
A: Melanotan 1 should be stored at -20°C (freezer) immediately upon receipt, protected from light and moisture. Lyophilized powder is stable when stored properly. Avoid repeated freeze-thaw cycles.
: What solvent should I use for reconstitution?
A: For most research applications, sterile water, PBS (pH 7.4), or cell culture medium is appropriate. Melanotan 1 is soluble in aqueous buffers. Contact our technical team for application-specific recommendations.
: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States.
: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through shanghaiapeptides.com with your volume requirements.
: What documentation do you provide for research compliance?
A: Every order includes batch-specific Certificates of Analysis (COAs) with HPLC and MS data. We also provide commercial invoices, packing lists, and customs documentation as needed. melanotan 1 peptide for sale
Quality Control: The Apeptide Standard
Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards. melanotan 1 peptide for sale
Analytical Methods
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HPLC Analysis: Every batch tested for purity (typically 99%+)
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Mass Spectrometry: ESI-MS for molecular weight confirmation (1,646.85 Da expected)
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Amino Acid Analysis: Sequence verification including D-Phe and Nle
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Chiral Analysis: Confirmation of D-Phe configuration
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N-Terminal Acetylation Confirmation: Essential for stability
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C-Terminal Amidation Confirmation: Essential for receptor binding
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
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Counterion Analysis: Acetate or TFA content specified
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Water Content: ≤8.0% by Karl Fischer
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Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Stability Studies: Ensuring integrity under various conditions
Batch Documentation
Each shipment includes:
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Certificate of Analysis with actual test results
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HPLC chromatogram (available upon request)
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Mass spectrometry data
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Chiral purity confirmation
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Batch number for traceability
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Expiration date and storage recommendations
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Reconstitution guidelines
Beyond Melanotan 1: A Complete Research Partner
Apeptide (Shanghai) Co., Ltd. is more than just a supplier of melanotan 1 peptide for sale. We are a full-service biochemical manufacturer committed to advancing research worldwide.
Our Capabilities
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Custom Synthesis: Develop proprietary peptides for your specific research needs
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Catalog Peptides: Hundreds of sequences available for immediate shipment
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Melanocortin Peptide Library: Including melanotan 1, melanotan 2, α-MSH, and related analogs
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Fluorescent Dyes: High-purity labeling agents for imaging and detection
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Amino Acids: Building blocks for synthesis and research
Quality Certifications & Compliance
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Licensed manufacturer with physical facility in Pudong District, Shanghai
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Rigorous quality control protocols
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Transparent documentation and traceability
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Experienced technical support team
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Strict adherence to research-use-only compliance
The Science Behind Melanotan 1: Selective MC1R Activation
Melanotan 1 was developed in the 1980s as part of a systematic effort to create stable, potent analogs of α-MSH for melanocortin research . Natural α-MSH is rapidly degraded, limiting its research utility. Melanotan 1 incorporates key modifications: melanotan 1 peptide for sale
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Norleucine (Nle) substitution: Replaces methionine, preventing oxidation
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D-Phenylalanine at position 7: Enhances resistance to enzymatic degradation
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N-terminal acetylation: Increases stability
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C-terminal amidation: Essential for receptor binding
These modifications result in a peptide with:
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Enhanced stability: Resists enzymatic degradation
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MC1R selectivity: Higher affinity for MC1R compared to other melanocortin receptors
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Potent melanogenic activity: Stimulates eumelanin production in melanocytes
Melanotan 1’s selective MC1R activation makes it a valuable research tool for:
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Studying MC1R-specific signaling pathways
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Investigating melanogenesis independent of other melanocortin receptor effects
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Developing photoprotection research models
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Understanding pigmentary disorders
The search for premium “melanotan 1 peptide for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need melanotan 1 for melanocortin receptor studies, pigmentation biology research, or specialized photoprotection investigations, we are your trusted manufacturing partner. melanotan 1 peptide for sale








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